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The DePaul Blue Demons (4-10 overall, 2-10 Big East) visit the Creighton Bluejays (16-5 , 12-4) for a Big East battle Wednesday night (9 p.m. ET) at the CHI Health Center in Omaha, Nebraska. Below, we analyze the DePaul-Creighton college basketball odds and lines, with picks and predictions.

Creighton is No. 11 in the Ferris Mowers Coaches Poll powered by USA TODAY Sports.

DePaul at Creighton:Odds, spread andlines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 2:52 p.m. ET.

  • Money line : DePaul +900 (bet $100 to win $900) | Creighton -1600 (bet $1,600 to win $100)
  • Against the spread/ATS : DePaul +15.5 (-115) | Creighton -15.5 (-105)
  • Over/Under : 143.5 (O: -110 | U: -110)

DePaul at Creighton: Three things to know

  1. The Bluejays defeated the Blue Demons, 69-62, on Jan. 30. Creighton then lost to Georgetown but has since won three in a row. The three in a row included an impressive win in a return game against the Hoyas and a monster 86-70 win over then-No. 4 Villanova. But that three-game win streak is also a bit distant in Creighton’s rearview mirror: the Bluejays haven’t played a game since Feb. 13.
  2. DePaul has struggled to score points and has scuffled in league play. The Demons are coming off a victory – just their third in the Big East in the last calendar year – at St. John’s. Prior to that win (on Saturday), DePaul had lost five in a row, scoring just 57.4 points per game in the process.
  3. Creighton failed to cover in their first effort against DePaul and has failed to cover their last two home games as a double-digit favorite. Since Dec. 14, 2020, the Bluejays are 1-5 ATS when tabbed as a home favorite by seven points or more. As a road dog of seven or more, the Demons have won three straight.
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DePaul at Creighton: Odds, lines, predictions and picks

Prediction

Creighton 77, DePaul 64

Money line (ML)

Uh, no.

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Against the spread (ATS)

Peg the Bluejays as being a bit vulnerable on the boards. The Blue Demons are trending the right way on the offensive glass. Senior PG Charlie Moore (24 points, six boards, eight assists vs. St. John’s) missed the first Creighton game, and he’ll be a big key at both ends of the floor.

TAKE THE BLUE DEMONS +15.5 (-115).

Over/Under (O/U)

DePaul comes up as a surprisingly good defense in analytic metrics. And the public hasn’t caught up: the Under is 11-1 in the Demons’ 12 games. The Bluejays have a 1-4 O/U record in their last five vs. a team with a losing straight-up record.

Peg this one being some trouble for a rust Creighton five. TAKE THE UNDER 145.5 (-110).

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